from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A proteinase of high specificity that is released by the kidney and acts to raise blood pressure by activating angiotensin.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. An circulating enzyme released by mammalian kidneys that converts angiotensinogen to angiotensin-I. Because its activity ultimately leads to formation of angiotensin-II and aldosterone, this hormone plays a role in maintaining blood pressure.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure
What happens is the kidneys in some ways, John, get overloaded and as a result of having all of that excess salt they start to release these hormones called renin, r-e-n-i-n, and what that causes is a shrinking of the blood vessels.
Drugs that block a hormonal cascade, known as the renin-angiotensin-aldosterone system
The discovery provides insight into a protein, renin, that is important in blood pressure regulation ...
"We are focusing on this system because we already know that inhibiting and controlling the production of renin, which is an enzyme that plays a role in the renin-angiotensin-aldosterone system, helps to preserve kidney function," Pool said.
Don't expect a routine test for that hormone, called renin, any time soon.
Future studies are needed to evaluate the effect of prophylactic treatment with nonanticoagulant medication such as renin-angiotensin-system inhibitors, they add.
ALIOF. PK) announced today that it has discontinued the development in partnership with MRK of an early stage compound (classified as a renin inhibitor) for the treatment of high blood pressure due to poor results from several clinical trials.
Salt sensitivity in obese individuals may be a consequence of increased sympathetic activity, decreased responsiveness to atrial natriuretic peptide, activation of the renin-angiotensin system or mechanical pressure on the kidneys that increases sodium reabsorption.
The third study, by a team led by Dr. Alderman, found that when an anti-renin drug was used in certain patients with low renin levels, it had the undesirable effect of increasing blood pressure.
It found that renin levels could also serve as a guide for prescribing add-on therapies for some patients.
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