peptidase

“CD26/dipeptidyl peptidase IV: A regulator of immune function and a potential molecular target for therapy.”

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“University, who worked at that time on translocation of proteins across the endoplasmic reticulum (ER) membrane, a process that involves cleavage of the leader peptide by signal peptidase, to Jeffrey Roberts in Cornell University who worked on E. coli RecA protein-directed cleavage of phage l repressor and its requirement for polynucleotide, and to Harvey Lodish at the M.I.T. who worked, among other subjects, on processing of viral polyproteins.”

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“Recent comments by Dr. Daniel Drucker, a professor at the University of Toronto and leader in diabetes and endocrinology, suggested dipeptidyl peptidase agents such as those being developed by Merck and Novartis have potential as effective second-line treatments for type 2 diabetes, according to Morgan Stanley.”

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“It was not until the mid-1990s that researchers saw another way: An enzyme called dipeptidyl peptidase four DPP4 broke down GLP, and by inhibiting it, researchers could boost GLP levels in the body.”

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“Those results, as well as data on a class of drugs known as dipeptidyl peptidase IV inhibitors DPIV, could provide a catalyst for OSI shares, the Wachovia analyst said.”

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“Both pills work by inhibiting an enzyme called dipeptidyl peptidase 4 DPP-IV, which breaks down hormones that help control blood sugar.”

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“Some of the preexisting protein translocation apparatus of the endosymbiont appears to have been commandeered, including molecular chaperones, the signal peptidase, and some components of the protein-targeting machinery.”

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“Osborne, who expects FDA approval of Novartis' Galvus in the first quarter, is one of a handful of analysts who believe Byetta will see significant competition from a new class of diabetes treatments known as dipeptidyl peptidase inhibitors.”

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“A peptidase enzyme capable of acting on any peptide linkage in a peptide chain.”

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