American Heritage® Dictionary of the English Language, Fourth Edition
- n. An enzyme in human urine that catalyzes the conversion of plasminogen to plasmin and is used in medicine to dissolve blood clots.
- n. biochemistry An enzyme, found in the urine, which converts plasminogen to plasmin, and is used in the treatment of deep vein thrombosis.
- n. protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis
“In a mouse study, Dickek and his team transplanted bone marrow containing macrophages that overproduce a protein-digesting enzyme known as urokinase into aged, atherosclerotic mice.”
“UW researchers learned that, inside some advanced plaques, macrophages that overproduce a protein-digesting enzyme known as urokinase into aged, atherosclerotic mice.”
“For instance, platelets might deliver an enzyme called urokinase to selectively disintegrate blood clots.”
“The first is a magnetic nanoparticle designed to target a molecule known as urokinase plasminogen activator receptor.”
“They have also been studied for their ability to inhibit urokinase, a protein produced by cancer cells that helps them invade healthy cells and spread.”
“Effect of thrombin, the thrombin receptor activation peptide, and other mitogens on vascular smooth muscle cell urokinase receptor mRNA levels.”
“Corticosteroid treatment suppressed other proangiogenic factors in hemangioma-derived stem cells, including urokinase plasminogen activator receptor, interleukin-6, monocyte chemoattractant protein 1, and matrix metalloproteinase 1.”
“But automatically blaming urokinase as the culprit without experimental evidence that it destabilized otherwise stable plaques would have been like seeing bright red trucks and firefighters at every flaming building and assuming they had set the blazes," Dichek said "In fact urokinase does have a protective effect at the right place and the right time, and we use it therapeutically as a clot-buster.”
“The researchers also observed that the increase in urokinase upped the activity of other protein-digesting enzymes that can eat away at the structural proteins that hold a plaque together.”
“Their data suggests that high levels of urokinase in plaque, leading to increases in plasminogen activation, may be causally related to plaque rupture and major cardiovascular events.”
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