antithrombin

• “A recently published study used thrombelastometry, plasmatic coagulation parameters and platelet count to assess the coagulation system in septic patients before and during a short-term antithrombin therapy.”

  PLoS ONE Alerts: New Articles

• “The European Medicines Evaluation Agency (EMEA) may decide early next year on approval of an anticoagulant protein, human antithrombin, that is produced in goat's milk to treat a hereditary disorder.”

  Scientific American

• “And certainly this choice of caprine platform has paid off enormously; GTC can now boast a historical milestone with the release of "ATryn®, our recombinant form of human antithrombin, the first transgenically produced protein to be approved anywhere in the world, having recently been approved by the European Commission for the prophylactic treatment of deep vein thrombosis in patients with hereditary antithrombin deficiencies that are undergoing surgical procedures," according to a company statement.”

  Boing Boing

• “Scientists at GTC Biotherapeutics, in Framingham, Mass., took DNA responsible for making human antithrombin and inserted it into goat embryos and established a small herd.”

  The Wall Street Journal: FDA Approves Drug Created With Engineered Goats Milk

• “Atryn will be marketed by Ovation Pharmaceuticals Inc., a closely held company in Deerfield, Ill. GTC Biotherapeutics estimates that about 1 in 2,000 to 5,000 people in the U.S. have an inherited antithrombin deficiency.”

  The Wall Street Journal: FDA Approves Drug Created With Engineered Goats Milk

• “The drug, Atryn, developed by GTC Biotherapeutics Inc. from the milk of a genetically altered goat, will be used to treat patients with a rare blood-clotting disorder known as hereditary antithrombin deficiency.”

  The Wall Street Journal: FDA Approves Drug Created With Engineered Goats Milk

• “Atryn's approval comes about a month after an FDA panel unanimously said Atryn was safe and effective in preventing life-threatening blood clots in certain patients who lack normal levels of antithrombin.”

  The Wall Street Journal: FDA Approves Drug Created With Engineered Goats Milk

• “It is an immunologic attack in which the antigen is a heparin-platelet factor 4 complex which when linked with an IgG antibody activates and aggregates platelets which form microparticles and induces a thrombin storm of coagulation which must be treated by stopping the heparin and giving antithrombin agents.”

  Should we consider HIT (heparin induced thrombocytopenia) in cases of DVT and PE?

• “The liver also produces the blood clotting agent prothrombin as well as two anticoagulants, heparin and antithrombin.”

  Simon & Schuster: THE NATURAL REMEDY BIBLE

• “Altered skin perfusion, reduced urine output alterations in coagulation parameters, increases D-dimers, low protein C, low antithrombin, increased prothrombin time/activated partial thromboplastin time unexplained alterations in mental status”

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