“I reasoned that the aspartame could have altered the catecholamine/indoleamine balance and thus account for her clinical difficulties.”
“My hypothesis in this study was that since aspartame led to an increase in norepinephrine precursors, coupled with a simultaneous decrease in serotonin precursors, the potential alteration in central nervous system catecholamine/indoleamine balance would pose a special challenge for patients with a mood disorder.”
“A role for inducible nitric oxide (iNOS), programmed death ligand-1 (PD-L1) and prostaglandin E2 (PGE2), but not indoleamine 2,3-dioxigenase (IDO), in the T cell inhibition was demonstrated.”
“In August we initiated a new clinical program in oncology with Incyte 24360, a selective orally available inhibitor of indoleamine 2, 3-dioxygenase”
“Many human tumors express indoleamine 2,3-dioxygenase (IDO), an enzyme which mediates an immune-escape in several cancer types.”
“The University of Illinois scientists identified the enzyme IDO (indoleamine 2,3 dioxygenase) as a molecular switch that induces depressive symptoms in some cases.”
“But high doses block inflammation by increasing expression of the enzyme indoleamine 2,3 dioxygenase, or IDO, an immunosuppressor, the researchers say.”
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