American Heritage® Dictionary of the English Language, Fourth Edition
- n. A drug, C6H10N4, that is a stimulant of the central nervous system and is used chiefly as an analeptic.
- n. a drug used as a circulatory and respiratory stimulant; larger doses cause convulsions in shock therapy; Metrazol is a trademark
- pent(a)- + (meth)ylene + tetr(a)- + az(o)- + -ol(e). (American Heritage® Dictionary of the English Language, Fourth Edition)
“We then added a subhypnotic dose of barbital and found that the combined action of this drug and nitrous oxide could be antagonized, and the increase in partial pressure of nitrous oxide needed to inhibit the righting reflex could be used as a measure of pentylenetetrazol action.”
“To measure the action of pentylenetetrazol Ahlgren proposed to employ its awakening action against central depressants.”
“Georg Theander, a topic to investigate, i.e. to measure the duration of action of pentylenetetrazol (Cardiazol), a convulsant at that time frequently used as an "artaleptic" to wake up people who had taken an overdose of a hypnotic or sedative, and also used as a forerunner of electroconvulsive therapy.”
“So I ran gerbils through a maze, timed them, and then injected them with Metrazol (the brand name for pentylenetetrazol, a central nervous system stimulant), and then ran them through the maze again.”
“Preclinical data • levetiracetam is not active against acute seizures, namely the maximal electroshock (MES) and pentylenetetrazol (PTZ) seizure tests • Levetiracetam also appears to lack anticonvulsant activity in other acute seizure tests utilizing chemoconvulsant agents,”
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