from The American Heritage® Dictionary of the English Language, 4th Edition
- adj. Producing physiological effects resembling those caused by the activity or stimulation of the sympathetic nervous system: a sympathomimetic hormone.
- n. A sympathomimetic drug or agent.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. That produces effects similar to those of the sympathetic nervous system
- n. Any medicine with this effect
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- adj. relating to epinephrine (its release or action)
It is officially classified as a sympathomimetic steroid.
(arteriosclerosis); symptomatic heart disease; moderate to severe high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy or unusual reactions to drugs called sympathomimetic amines (for example, pseudoephedrine); seizures; glaucoma; a history of problems with alcohol or drugs; agitated states; taken a monoamine oxidase inhibitor (MAOI) within the last 14 days.
A little known fact is that the popular 'Vick inhaler' contains 50mg of methamphetamine described on the label by the synonym deoxyephedrine in free base oil form; however, it is not the psychoactive D-isomer of the drug but L-methamphetamine or levmetamfetamine, which has no psychostimulant properties but retains some sympathomimetic activity.
L-amphetamine has some pressor/sympathomimetic effects which pseudoephedrine/phenylephrine/ephedrine all have, this vasoconstrictor type effect is responsible for the relief of rhinitis but virtually no psychoactive effects; D-amphetamine has both in spades.
Blockade of this site inhibited the neuronal uptake of no repinephrine from the region of the adrenergic receptors, thus potentiating its action; however, blockade of the site also inhibited uptake of tyramine, whose sympathomimetic action depends on release of norepinephrine from neuronal storage sites, thus inhibiting its action.
In 1960, I was invited to present a paper on some of my studies on receptors for sympathomimetic amines at a CIBA Foundation conference on Adrenergic Mechanisms held at CIBA House in London.
In writing the 1955 review on the "Pharmacology of vascular smooth muscle," I had become very interested in the mechanisms by which sympathetic postganglionic denervation and certain drugs like cocaine markedly potentiate the response of effector organs to epinephrine and norepinephrine, yet markedly reduce the response to the sympathomimetic tyramine.
S. von Euler, A specific sympathomimetic ergone in adrenergic nerve fibers (sympathin) and its relations to adrenaline and nor-adrenaline, Acta Physiologica Scandinavica 12 (1946): 73-97.
Half the time she didn't know where she was, whisked in the car from one building to another, making notes of names and meetings and a long discussion on sympathomimetic amines which left her with cramp in her hand and a complete ignorance of the subject.
Indirect sympathomimetic effects c.f. amphetamines
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