- thym(us) + -cyte. (American Heritage® Dictionary of the English Language, Fourth Edition)
“Precisely how these two T cell lineages are generated from common thymocyte progenitor cells remains to be fully elucidated and is under intense investigation.”
“Because thymic tumors can support thymocyte development, aberrant T-cell generation has been suggested as a cause.”
“The development of CMV CNS disease is associated with risk factors (T-cell depletion, anti-thymocyte globulin, umbilical cord blood transplantation) that cause severe and protracted T-cell immunodeficiency (8 of 11 cases), a history of recurrent CMV viremia treated with multiple courses of preemptive ganciclovir or foscarnet therapy (11 of 11 cases), and ganciclovir-resistant CMV infection (11 of 11 cases).”
“In addition, FACS analysis of thymocytes derived from TetO-Dkk1 and K5rtTA-ST mice following 4 weeks of Dox feeding using antibodies against CD4, CD8, TCRβ, CD25 and CD44 was used to assess differences in thymocyte subset frequency.”
“Carter C, Gimenez-Conti IB, Richie ER (2002) Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus.”
“Regulation of Wnt signaling has also been shown to impact both early thymocyte and thymic epithelial development.”
“Following 4 weeks of Dox feeding, FACS analysis of thymocytes derived from either male or female TetO-Dkk1 mice showed no changes in the frequency of individual thymocyte subsets.”
“A key role for the Wnt signaling cascade in controlling thymocyte cellularity and differentiation is apparent from studies using Tcf-1/LEF-1 knockout mice, as well as a number of complementary gain-of-function and loss-of-function studies”
“Meeldijk J, Moerer P, Jay P, van de Weerdt BC, et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription.”
“To examine if DKK1-mediated inhibition of canonical Wnt signaling in TECs, impacted T cell development, total thymocyte numbers were counted.”
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