“Aberrant expression of circadian clock genes could have important consequences on the transactivation of downstream targets that control the cell cycle and on the ability of cells to undergo apoptosis.”
“It interacts directly with the PER proteins, and it negatively regulates the ARNTL-CLOCK and ARNTL-NPAS2 complexes that induce the transactivation of”
“Additional transactivation assays were carried out co-transfecting FOXL2 and increasing amounts of PIAS1 and UBC9 in COS-7 cells, to test whether FOXL2 transcriptional activity, like that of SOX9, is affected by PIAS1 in both SUMO-ligase-dependent and independent manners”
“Oh HJ, Kido T, Lau YF (2007) PIAS1 interacts with and represses SOX9 transactivation activity.”
“To assess any effects of FOXL2 sumoylation on transcriptional activity, we carried out a series of transactivation assays with luciferase as a reporter gene, driven by the 972 bp promoter of the human”
“PHDs-mediated hydroxylation targets HIF-1α for proteasomal degradation via the ubiquitination-dependent Von Hippel-Lindau (VHL) complex, while FIH-1-mediated hydroxylation leads to the inhibition of HIF-1 transactivation.”
“Bcl-2 cooperates with high cell density conditions to induce nuclear HIF-1α protein and HIF-1 transactivation activity.”
“Pellegrini E, Anglade I, Blaise O, Laudet V, et al. (2002) Molecular characterization of three estrogen receptor forms in zebrafish: binding characteristics, transactivation properties, and tissue distributions.”
“Reports on the molecular mechanisms linking cannabinoid receptors to various kinases suggest that these receptors activate AKT through G-proteins, while activating ERK1/2 through EGF receptor transactivation”
“Fischer OM, Ullrich A (2004) Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17) - mediated transactivation of the epidermal growth factor receptor.”
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