Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A change of location.
  • n. Genetics A transfer of a chromosomal segment to a new position, especially on a nonhomologous chromosome.
  • n. Genetics A chromosomal segment that is translocated.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Removal of things from one place to another; displacement; substitution of one thing for another.
  • n. A transfer of a chromosomal segment to a new position, especially on a nonhomologous chromosome; the segment so transferred.

from the GNU version of the Collaborative International Dictionary of English

  • n. removal of things from one place to another; substitution of one thing for another.

from The Century Dictionary and Cyclopedia

  • n. The act of translocating, or the state of being translocated. Also translocalization.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. (genetics) an exchange of chromosome parts
  • n. the transport of dissolved material within a plant

Etymologies

trans- +‎ location (Wiktionary)

Examples

  • This genetic event was termed a translocation—the flip-flop transposition of two pieces of chromosomes.

    The Emperor of All Maladies

  • Present view of protein translocation across the ER membrane.

    The Nobel Prize in Physiology or Medicine 1999

  • These forms of leukemia share a common molecular abnormality called a translocation in which a gene on chromosome 11 breaks and becomes joined with one of many genes on different chromosomes.

    Pediatric cancer research

  • Just over half, 51%, had one or more cancer gene mutations or an abnormality called a translocation, in which a section of DNA gets incorporated into the wrong chromosome.

    Multiple gene test allows more targeted treatment of cancer

  • The rearranged genetic region, called a translocation, leads to the production of a fusion gene and an abnormal protein and, ultimately, to leukemia.

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  • Beginning in 1972, she made a number of remarkable discoveries, including the landmark finding that an abnormally short chromosome associated with chronic myelogenous leukemia (CML) was not a chromosome deletion, as many scientists had thought, but an exchange (known as a translocation) of segments between two chromosomes.

    Health News from Medical News Today

  • The Leukemia BCR/ABL FISH Probe is a molecular diagnostic test kit that uses DNA probes for accurate detection of Philadelphia translocation, which is a specific chromosomal abnormality associated with chronic myelogenous leukemia ( "CML"), acute lymphoblastic leukemia ( "ALL") and acute myelogenous leukemia ( "AML").

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  • Fewer than 1 percent of hereditary cases are due to a different type of abnormality on the same chromosome, a rearrangement of genetic material known as a "translocation" or an "inversion."

    Beckwith-Weidemann Syndrome

  • Gleevec targets the single genetic change that causes CML, a "translocation" in which two pieces of DNA swap places and leave one gene stuck in the "on" position.

    Curing Cancer

  • Louw was pleased, however, that submissions also focused on non-lethal solutions such as translocation, contraception and range expansion.

    ANC Daily News Briefing

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