from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. An antipsychotic drug used as a sedative and in the treatment of schizophrenia.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An antipsychotic drug used in the treatment of schizophrenia etc.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. an antipsychotic drug (trade name Clozaril) used as a sedative and for treatment-resistant schizophrenia; know to have few side effects


c(h)lo(ro)- + alteration of (dia)zepine (diazep(am) + -ine2).
(American Heritage® Dictionary of the English Language, Fourth Edition)


  • I went back to the Grove, where the doctor suggested I take a new drug called clozapine.

    Henry’s Demons

  • He then returned to Anselm ward at St. Martin’s, where he was supposedly taking a newly prescribed anti-psychotic called clozapine, which seemed to have a positive impact.

    Henry’s Demons

  • Only one antipsychotic—clozapine, available as a generic drug—has been shown in clinical trials to be effective for Parkinson's psychosis symptoms, but Dr. Weintraub and his colleagues found that only 2% of patients were being prescribed this medication.

    Drug Concerns in Parkinson's

  • Despite these mishaps, Cygnet succeeded in increasing the amount of clozapine Henry received and in breaking the vicious circle of one step forward, two steps back, whereby Henry would make a slow partial recovery and then suffer an acute relapse.

    Henry’s Demons

  • These were to stop him running away—much more difficult for him to do at Cygnet than elsewhere—and to ensure that he took his clozapine, the only anti-psychotic drug which appeared to do him any good.

    Henry’s Demons

  • His worst breakdowns and brainstorms—which he later nicknamed his “polka-dot days,” though the phrase does not quite convey the terrors which then seemed to possess him—mostly struck him when he was secretly not taking the clozapine.

    Henry’s Demons

  • A second disappointment was equally serious: We assumed that the staff at Fitzmary 2, more numerous and better trained than at DVH, would be able to persuade him to take the clozapine.

    Henry’s Demons

  • The only way to get him to take the clozapine was to sit with him until he did so, which might be a matter of hours.

    Henry’s Demons

  • But a test in December, about five months after he had moved to the Bethlem Royal, showed that there was no sign of clozapine in his blood.

    Henry’s Demons

  • By the end of 2007, the clozapine was having an effect, and Jan and I thought Henry was more engaged in the world and his thoughts and actions were less driven by hallucinations and voices.

    Henry’s Demons


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