from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A tricyclic compound, C19H24N2, used to treat depression and enuresis.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun chemistry a
tricyclic heterocyclic compoundused to treat depression
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression
from The American Heritage® Dictionary of the English Language, 4th Edition
His data was overwhelming, his enthusiasm even stronger, but G22355—by then known as imipramine—was hardly taking the world by storm, and Kuhn was roundly ignored.
Finally, he experienced some relief when he switched to an old-fashioned tricyclic antidepressant called imipramine.
The other showed that an antidepressant called imipramine, which was known to block NPC1, seemed to prevent infection as well.
A class of older antidepressants called tricyclics, such as amitriptyline (Elavil) or imipramine (Tofranil), are effective at staving off chronic tension-type headaches in many people who have not found relief with over-the-counter medications.
This “vital disturbance,” Kuhn claimed, is what imipramine was uniquely suited to treat.
Endogenous depression was exactly the disease that imipramine cured, and the proof that you had been sick was that imipramine cured you.
The studies showed that this was true, whether or not the patients took Paxil, a selective serotonin reuptake inhibitor (SSRI), or imipramine, a tricylcic, an older generation of anti-depressant medication.
And when Axelrod showed that imipramine worked the latter way, blocking the reuptake of norepinephrine, it was easy to believe that the catecholamine hypothesis was correct.
Amphetamines only made you feel better, but imipramine made you feel well—which meant that you must have been sick all along.
At a time when psychoanalysis was the mainstay of psychiatry, he was arguing that imipramine could “bring a complete change in the situation within a few days, which could not be achieved by intensive prolonged psychotherapy.”