from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A substance produced by metabolism.
- n. A substance necessary for or taking part in a particular metabolic process.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any substance produced by, or taking part in, a metabolic reaction.
from the GNU version of the Collaborative International Dictionary of English
- n. A product of metabolism; a substance produced by metabolic action, as urea.
from The Century Dictionary and Cyclopedia
- n. A product of or substance resulting from metabolism, especially from retrograde metabolism, or catabolism.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. any substance involved in metabolism (either as a product of metabolism or as necessary for metabolism)
First they took cerebral spinal fluid from 132 juvenile rhesus monkeys and analyzed it for a serotonin metabolite, called 5-HIAA, that’s considered a reliable indicator of how much serotonin the nervous system is processing.
For example, phenoxybenzamine (Dibenzyline®), a drug given to relieve hypertension, is biotransformed into a metabolite, which is the active agent.
This agent was not described as metabolite in report, but it should be noted that diazepam breaks down into oxazepam.
The case focuses on a patent that covers the concept of adjusting the dosage of a drug, thiopurine, based on the concentration of a particular chemical called a metabolite in the patient's blood.
The machine was not calibrated to recognize there can be an interfering substance, known as metabolite, which exists naturally in the metabolism of some patients and in rare instances can interfere with cyclosporine causing the machine to show artificially low levels of the drug.
This is in contrast to the pharmacokinetics of Clopidogrel's active metabolite, which is affected by genetic variations in CYP2C19.
At times of stress, he argues, we are physiologically in "survival mode", prompting the release of testosterone and its bioactive metabolite, DHT.
Wang and his coauthor, Dr. Robert Gerszten, are co-inventors on patent applications related to metabolite predictors of diabetes.
A metabolite contributing to morbidity and mortality.
In this way, they move from metabolite analysis or biochemical markers to disease diagnosis involving an enzyme, transport or structural protein, etc. to the gene defect and mutation analysis if feasible.