-statin

yaybob In case you’re interested, these sixteen substances are each one of three categories of chemicals: the first one and the last two are hormones. The next four are three proprietary names and the generic name of an antifungal drug. The other nine are cholesterol inhibitors and are what is meant by the statins in medicine.

nystatin is the generic name for an antifungal first developed in N.Y. state and marketed as Korostatin®, Mycostatin®, and Flagystatin®

The next nine substances (Pi, F, Pr, R, C, Si, L, M, and A) are structurally related to one another, but not to the three hormones (Ang, End and Som,) or the antifungal drug with four names. They are all HMG-CoA inhibitors (they inhibit cholesterol synthesis). Only F, Pr, R, Si, L, M, and A are prescribed in the US (as Lescol®, Pravachol®, Crestor®, Zocor®, Mevacor® and Lipitor® ; C, formerly sold as Baycol® but later withdrawn, and M, a natural occurring precursor for synthesizing some of the others, are too toxic for use; Pi used in Asia.

Somatostatin (from the brain and gut), endostatin (cleaved from collagen), and angiostatin are naturally occurring hormones. Angiostatin and endostatin inhibits tumor neovascularization, an essential part of tumor growth. They are being studied for therapeutic use against cancers. Somatostatin antagonizes insulin and growth hormone (somatotropin).
Dec 6, 2008

yaybob pravastatin, fluvastatin, pitavastatin and nystatin can be added to this list.

The first three, like rosuvastatin, cerivastatin, simvatatin, lovastatin, mevastatin, and atorvastatin are cholesterol lowering synthetic chemicals called HMG-CoA reductase inhibitors. Nystatin is an antibiotic (somatotatin and endostatin are naturally occurring hormones).
Dec 4, 2008