American Heritage® Dictionary of the English Language, Fourth Edition
- n. A substance that closely resembles an essential metabolite and therefore interferes with physiological reactions involving it.
- n. medicine Any substance that competes with, or inhibits the normal metabolic process, often by acting as an analogue of an essential metabolite
- n. an antineoplastic drug that inhibits the utilization of a metabolite
“When this process is allowed to proceed normally it is also called “metobolizing,” somethotrexate is also called an “antimetabolite.””
“Methotrexate is currentlythe only antimetabolite approved by the FDA as a treatment for psoriasis.”
“They prevented rabbits from producing antibody against human serum albumin by treating them for two weeks with the antimetabolite, 6-Mercaptopurine.”
“Therefore, acyclovir is transformed into its corresponding nucleotide which is the active antimetabolite and the growth of the virus is inhibited (Figure 3).”
“This suggested that other enzymes might also recognize such a side chain as a pentose and that nucleoside analogs of this kind might have antimetabolite properties.”
“In 1940, Woods and Fildes (1,2) had put forth the antimetabolite theory to explain the action of sulfonamides on bacteria, suggesting that the sulfonamides interfered with the utilization of a necessary nutrient, para-aminobenzoic acid.”
“Learn about the research that led to the use of the antimetabolite drugs 6-mercaptopurine”
“Methotrexate Toxicity - antimetabolite/antifolate for cancer/autoimmune disease”
“Methotrexate is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.”
“ALTH): The company is commercializing Folotyn ™ (pralatrexate injection), an antimetabolite approved for the treatment of patients with relapsed or refractory PTCL.”
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