GNU Webster's 1913
- adj. (Genetics) of, pertaining to, or causing a type of mutation consisting of the insertion or deletion of one or more nucleotides in the nucleic acid structure of a gene, when the number of base pairs inserted or deleted is not a multiple of three. If the addition or deletion occurs in multiples of three, the unaffected nucleotides in the genome remain in the proper order ("frame") to be correctly translated into protein; in such cases of insertions or deletions not causing a frame shift, a functional though altered protein may be produced by the organism.
Frameshiftmutations cause more profound changes in the composition of the protein resulting from translation of the mutated gene.
“GU anomalies syndrome: These individuals usually carry changes known as nonsense or frameshift mutations that affect one working copy of the WT1 gene.”
“Nylonase was a frameshift, much antibiotic and viral drug resistance is due to gene cassettes, transplanted finches develop new beak types in 20 years, multiple instances of plant speciation (same species) in the Pacific NW in the past 60 years …”
“I think you'll find the e-coli changed via a frameshift.”
“There are also some examples of genes that can be turned on / off via regulated frameshift mutations.”
“He certainly knows next to nothing about biology he argued that frameshift mutations require 2 mutations… right next to one another.”
“Did that last post undergo a frameshift mutation, or what?”
“Ugt5b5 gene has four nonsense mutations and two frameshift mutations and appears to be a pseudogene.”
“Our friend sitting by the theatre at 8: 45 could've avoided distress at this sudden frameshift by rejecting the human tendency to turn 'blocks of time' into abstractions and invest them with qualities.”
“Given the A1 antigen allele plus encoding of the rhesus factor in combination with lack of B antigen and the O antigen frameshift mutation, we conclude that the Saqqaq individual had blood type A+”
“ORF, leading to a frameshift mutation 20 codons before the end of the coding sequence.”
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