Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A lipid that contains one or more carbohydrate groups.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. an association of a carbohydrate and a phospholipid, such as phosphatidylinositol, found in cell membranes

Etymologies

glyco- +‎ lipid (Wiktionary)

Examples

  • Domenech P, Manca C, Su H, Barczak AK, et al. (2004) A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response.

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  • Our data provide evidence that Stx/StxB, upon binding to its glycolipid receptor at the cell surface, is able to increase the formation of endocytic clathrin-coated structures directly detected by electron microscopy and indirectly by the appearance of AP-2 spots at the plasma membrane.

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  • Kiyokawa N, Katagiri YU, Taguchi T, Suzuki T, et al. (2000) Globotriaosyl ceramide (CD77/Gb3) in the glycolipid-enriched membrane domain participates in B-cell receptor-mediated apoptosis by regulating lyn kinase activity in human

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  • Clathrin-dependent endocytosis is a main entry mechanism for the glycolipid-binding Shiga toxin (Stx), although clathrin-independent pathways are also involved.

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  • It has recently been shown that the extra-cellular domain of the trans-membrane receptor Fas interacts strongly with Gb3 through a glycolipid-binding motif

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  • Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1.

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  • Motivated by our previous findings that Stx can mediate its own uptake and affect signaling, we set out to investigate if Stx, although binding to a glycolipid, was able to increase the formation of endocytic clathrin coat structures at the plasma membrane and if such increase in clathrin coats might be mediated by signaling through the Syk kinase.

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  • -- Later in 2009, we expect our partner Morphotek, a wholly-owned subsidiary of Eisai, to initiate a first phase 1 clinical trial with MT228, a glycolipid-binding human antibody.

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  • J Biol Chem 278: 29880-29889. de la Salle H, Mariotti S, Angenieux C, Gilleron M, Garcia-Alles LF, et al. (2005) Assistance of microbial glycolipid antigen processing by CD1e.

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  • Later in 2009, we expect our partner Morphotek, a wholly-owned subsidiary of Eisai, to initiate a first phase 1 clinical trial with MT228, a glycolipid-binding human antibody.

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