from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A strongly alkaline crystalline compound, NHC(NH2)2, formed by the oxidation of guanine and found in the urine as a normal product of protein metabolism. It is commonly used in the organic synthesis of plastics, resins, and explosives.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A strong base HN=C(NH2)2 obtained by the oxidation of guanine
from the GNU version of the Collaborative International Dictionary of English
- n. A strongly alkaline base, NH2.CNH.NH2, formed by the oxidation of guanin, and also obtained combined with methyl in the decomposition of creatin. Boiled with dilute sulphuric acid, it yields urea and ammonia.
And so that's the project that I pursued for that year, and it's continuing now as well, and found that a specific purine derivative called guanidine had inhibited the cell growth by approximately 60 percent.
Preferred modifiers include NaOH, urea sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, and guanidine hydrochloride.
In the presence of guanidine, viral RNA is not synthesized, and it has been believed that guanidine acts in some manner on the viral RNA-replicase.
At concentrations which are inhibiting for the virus, however, guanidine does not observably influence metabolism and cellular growth.
However, we became aware that methionine and choline neutralize the inhibiting effects of guanidine.
Sensitivity to guanidine may disappear upon mutation.
It is difficult to conceive that the presence, at some particular locus, of a nucleotide already abundantly represented along a long chain could modify the properties of the chain so that, for example, a difference of temperature of one-tenth of one degree or the presence of 0.0002 M guanidine would notably affect the structure and function of the molecule.
Such methylation would be effected by a virus-determined enzyme which is sentitive to guanidine and to cellular metabolites possessing a guanyl group.
A number of experiments have led us to believe that the guanidine must block the activity of a virus-determined transmethylase.
The experiments are generally made in environments which may contain anti-effectors, as is the case for the couple methionine/guanidine.
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