ligand

• (A ligand is a molecule that binds to the receptor to form a biologically active complex.) "In bad times, the ligand is not made and the nuclear receptor (DAF-12) causes the animals to go into the long lived dauer stage, shutting down the microRNAs and the developmental clock," he said. —  Baylor College of Medicine News
• I examine how tensile force exerted on a selectin-ligand complex in vivo could favor the more extended, high-affinity conformation. —  CiteULike: Everyone's library
• Mutations at two positions located far from position − 1 (α2-1 and β2-4) expand specificity to include D, and it is likely that these mutations alter the ligand orientation and allow a D side chain to interact with the R side chain at position β3-5, which sits between ligand positions − 1 and − 3 36 —  PLoS Biology: New Articles
• These effects may be caused by ligand orientation changes, which may allow for more favorable interactions between the PDZ domain and ligand residues upstream of position − 2. —  PLoS Biology: New Articles
• As a further test, we found that a Herpes virus ligand (peptide 12) matching the specificity profiles of SCRIB and ZO-1 PDZ domains bound to both, while another ligand (peptide 13) matching only the ZO-1 PDZ domain specificity profile interacted only with this domain. —  PLoS Biology: New Articles

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