Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A small polypeptide present in the cells of all eukaryotes; it plays a part in modifying and degrading proteins

Etymologies

Sorry, no etymologies found.

Examples

  • Consequently, degradation of both abnormal and normal shortlived proteins was also inhibited, demonstrating that the same enzyme that is involved in ubiquitin activation for histone modification, is also involved in activation of ubiquitin for modification of substrates destined for degradation.

    Aaron Ciechanover - Autobiography

  • (and I believe that in several others as well) that ubiquitin was limited to eukaryotes, and its apparent presence in bacteria was due to the contamination of the bacterial extract with the yeast extract in which the bacteria were grown: growing the bacteria in a synthetic medium containing carbon (glucose) and nitrogen (ammonium chloride) sources and vitamins resulted in "disappearance" of ubiquitin from the preparation.

    Aaron Ciechanover - Autobiography

  • While it appeared that the term ubiquitin was not justified anymore, as it is clearly not ubiquitous, we stopped using the term APF-1 and adopted the term ubiquitin for the modifying protein in the newly discovered proteolytic system.

    Aaron Ciechanover - Autobiography

  • Since the molecule was subsequently found in numerous different tissues and organisms – but not in bacteria – it was given the name ubiquitin (from Latin ubique, "everywhere") (fig. 1).

    The Nobel Prize in Chemistry 2004 - Information for the Public

  • By using antibodies to ubiquitin, ubiquitin-protein-conjugate could be isolated from cells where the cell proteins had been pulse-labelled with a radioactive amino acid not present in ubiquitin.

    The Nobel Prize in Chemistry 2004 - Information for the Public

  • Recently, scientists discovered that a protein called ubiquitin is involved in some cases of FTD.

    WN.com - Articles related to Scientists uncover mysterious workings of cholera bacteria

  • The tagging reaction is catalyzed by enzymes called ubiquitin ligases.

    WN.com - Articles related to Scientists uncover mysterious workings of cholera bacteria

  • Ubiquitination is characterized by the conjugation of a small protein called ubiquitin to various other proteins to regulate their degradation or activities.

    RedOrbit News - Technology

  • ICP0 attaches so-called ubiquitin marks, which instruct the cell to get rid of the very proteins that protect it.

    PhysOrg.com - latest science and technology news stories

  • Hybrigenics 'research program explores the role of enzymes known as ubiquitin-specific proteases (USP) in the degradation of onco-proteins, and the effectiveness of proprietary USP inhibitors in treating various types of cancer.

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