Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities.
  • n. An instrument used in surgical osteoclasis.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A large multinuclear cell associated with the resorption of bone
  • n. An instrument for performing osteoclasis.

from the GNU version of the Collaborative International Dictionary of English

  • n. Same as myeloplax, a large multinucleate cell within the bone, which functions in the absroption and removal of bone tissue.
  • n. An instrument for performing osteoclasis.

from The Century Dictionary and Cyclopedia

  • n. In surgery, an apparatus for fracturing bones in order to correct deformities.
  • n. A large multinucleated cell supposed to be concerned in the absorption of bone-tissue. Originally osteoklast (Kölliker). Also called giant cell, myeloplax, and myeloplaque.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. cell that functions in the breakdown and resorption of bone tissue

Etymologies

osteo- + Medieval Latin -clastēs, breaker (from Late Greek -klastēs, from Greek klastos, broken, from klān, to break).
(American Heritage® Dictionary of the English Language, Fourth Edition)
osteo- (“bone”) +‎ -clast (“break”) (Wiktionary)

Examples

  • Slide 26: (OPG), also known as osteoclast inhibitory factor (OCIF) is a soluble decoy receptor for RANKL (111).

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  • RANKL, also known as osteoclast differentiation factor (ODF), tumor necrosis factor - related activation-induced cytokine (TRANCE) and osteoprotegerin ligand, is a member of the TNF ligand family (106) produced in osteoblastic lineage cells and activated T cells

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  • Skeleton Crew osteoclast The drugs target a protein called RANK Ligand, which helps regulate cells called osteoclasts that break down bone.

    Week in Words

  • Incidentally, osteoclast is a type of cell that attacks the bone.

    CNN Transcript May 3, 2007

  • An osteoblast engaged in the absorption instead of the formation of bone is called an osteoclast.

    Text Book of Biology, Part 1: Vertebrata

  • When interference is called for, if the callus is not yet firmly consolidated, it may be possible, under an anæsthetic, to bend the bone into position or to re-break it, either with the hands or by means of a strong mechanical contrivance known as an osteoclast.

    Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition.

  • Teitelbaum S, Ross FP (2003) Genetic regulation of osteoclast development and function.

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  • (C) Histomorphometric quantification of the trabecular bone volume and osteoclast surface per bone surface (OcS/BS).

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  • Tnfrsf11b, the gene encoding the osteoclast-inhibitory factor Opg, is known to be induced by canonical Wnt signaling in osteoblasts

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  • Col1a1-Krm2 mice display a cell-autonomous differentiation defect, impaired canonical Wnt signalling and decreased production of the osteoclast inhibitory factor Opg. To determine whether the observed effects of Krm2 on bone remodeling are physiologically relevant, we analyzed the skeletal phenotype of 24 weeks old

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