toxine

The receptors so produced pass into the blood, where they combine with the toxine which has been absorbed; the combination is a stable one, and the toxine is thus prevented from combining with the tissue cells.

Disease and Its Causes William Thomas Councilman

This antitoxine neutralizes the effects of the diphtheria toxine, and then the body develops strength to drive off the bacteria which have obtained lodgment in the throat.

The Story of Germ Life

In the case of the susceptible animal the receptors of the cells of the different organs combine with the toxine to a greater or less extent, which explains the fact that different degrees of injury are produced in the different tissues; the toxine of tetanus, or lockjaw, for example, combines by preference with the nervous tissue, that of diphtheria with the lymphatic tissue.

Disease and Its Causes William Thomas Councilman

Unless the living cells have receptors which will enable the combination with the toxine to take place, no effect can be produced by the toxine and the cells are not injured.

Disease and Its Causes William Thomas Councilman

A very ingenious theory which well accords with the facts has been given by Ehrlich in explanation of the production of antitoxine and of the reaction between toxine and antitoxine (Fig. 18).

Disease and Its Causes William Thomas Councilman

The antitoxine which is formed during the disease, and the production of which in the horse can be enormously stimulated by the injection of toxine, represents merely the excess of cell receptors, and when the serum of the horse containing them is injected in a case of diphtheria the same combination takes place as in the case of receptors provided by the patient.

Disease and Its Causes William Thomas Councilman

It is known that in accordance with the general law of injury and repair, a loss in any part of the body stimulates the tissue of the same kind to new growth and the loss is thus repaired; it is assumed that the cell receptors which combine with the toxine are lost for the cell which then produces them in excess.

Disease and Its Causes William Thomas Councilman

Mussel-poisoning was formerly supposed to be due to the copper in them derived from ships 'bottoms, but it is more probably the result of the formation of a toxine during life, and not after decomposition has set in.

Aids to Forensic Medicine and Toxicology

The surface of the cell (_n_) is covered with receptors some of which (_b_) fit the toxine molecule, (_a_) allowing the toxine to act upon the cell.

Disease and Its Causes William Thomas Councilman

It has been found that the production of antitoxine can be so stimulated by the injection of toxine that the blood of the animal used for the purpose contains large amounts of antitoxine.

Disease and Its Causes William Thomas Councilman