from The American Heritage® Dictionary of the English Language, 4th Edition
- adj. Passing or occurring across a membrane.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. traversing a cellular membrane
- adj. of or pertaining to a transmembrane protein or segment
- n. a transmembrane protein, or the transmembrane portion of a protein
The parts of the molecule that pass through membrane are called transmembrane domains.
Given this overlap in infection and human cell engraftment patterns, it may also be possible to deliver molecules in addition to cytokines, such as transmembrane receptors, that require direct cell-to-cell contact to mediate their effects.
Those "transmembrane" protein gateways match the architecture of the membrane, with a hydrophobic center section bounded by two water soluble, or hydrophilic, layers.
Peter Mitchell who proposed an elaborate but basically "unphysical" mechanism for this transmembrane proton transport received a Nobel Prize.
The mutation, called G551D, is in a gene called the cystic fibrosis transmembrane conductance regulator.
Langzhou Song et al., “Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore,” Science 274 1996, 1859–1866.
For example, we know that cystic fibrosis manifests due to an irregularity in the ability to produce cystic fibrosis transmembrane conductance regulator (CFTR).
It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin.
It turned out to be a cAMP-activated choride channel and was termed cystic fibrosis transmembrane conductance regulator (CFTR).
Returning to the case of cystic fibrosis, a PMG for an individual without the disease referred to one of a variety of transmembrane ion-channel templates along with all the epigenetic factors involved in the generation of the normal polypeptide product.
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