American Heritage® Dictionary of the English Language, Fourth Edition
- n. A calcium-binding protein found in all nucleated cells that affects the activity of many calcium-sensitive enzymes, including those involved in muscular contraction.
- cal(cium) + modul(ate) + -in. (American Heritage® Dictionary of the English Language, Fourth Edition)
“The team, which included researchers from Vanderbilt University, showed in theory that it might be possible to use drugs that maintain the positive effects on heart function of a known enzyme called calmodulin kinase II (CaM kinase) while reducing its negative effects.”
“Researchers knew that an enzyme called calmodulin kinase II is overactive in several heart diseases and believed it played a role in the leaky channels - a tiny pore that controls release of calciu through the cell's membrane.”
“While a molecule known as calmodulin is known to provide feedback control for calcium ion channels, the specific mechanism by which it down-regulates an ion channel is not clear.”
“These get picked up by a receiver, a protein called calmodulin which turns this calcium signal into action by switching various parts of the cell's machinery on or off.”
“What's more, DAPK has physical similarities to many of the other kinases controlled by calmodulin, meaning many of them are likely to interact with calmodulin in the same, or similar ways.”
“Another early, promising result on this front comes out of the University of Georgia where Dr. Joe Tsien has found a way to interfere with an enzyme, calcium/calmodulin-dependent protein kinase II (CaMKII), crucial to memory formation.”
“Ca2+/calmodulin kinase kinase α is dispensable for brain development but is required for distinct memories in male, though not in female, mice.”
“Calcium/calmodulin kinase kinases β has a male-specific role in memory formation.”
“This is likely related to the calcium-binding protein calmodulin, suggesting Ca2+ involvement in mediating growth responses.”
“In the study, Williams and colleagues at the University of Texas Southwestern Medical Center in Dallas created a group of mice with genes that made a surplus of a protein called calmodulin-dependent protein kinase, or CaMK.”
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