American Heritage® Dictionary of the English Language, Fourth Edition
- n. Any of a class of enzymes that catalyze the linkage of two molecules, generally utilizing ATP as the energy donor. Also called synthetase.
GNU Webster's 1913
- n. (Biochem.) An enzyme which catalyzes creation of a covalent bond between two substrates, resulting in a larger product which is a combination of the two starting materials; especially, DNA ligase, an enzyme which creates a phosphate bond between 5′ and 3′ ends of a DNA chain, resulting in a longer chain of DNA. DNA ligase is important in normal biosynthesis of DNA in the replication cycle of cells.
- From Latin lig(are) ("to bind") + -ase. (Wiktionary)
- Latin ligāre, to bind; see leig- in Indo-European roots + -ase. (American Heritage® Dictionary of the English Language, Fourth Edition)
“S., and Ciechanover, A. (1983) "Components of ubiquitin-protein ligase system".”
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“DNA polymerase, Pol I, extends the DNA from the free 3'-OH using its exonuclease activity to replace the nucleotide of the damaged base, as well as a few downstream, followed by sealing of the new DNA strand by DNA ligase.”
“Prediction and evolution of E3 ubiquitin ligase targets”
“One of them is an RNA ligase with weak polymerase activity.”
“Beta lactamases have kept these activities, despite structural changes which have resulted in losing DD-peptidyl ligase activity, if these activities are kept, then the enzyme is more robust than Axe contends but to be fair this is harder to monitor in the kinds of experiments Axe did.. gutbag”
“At this point, however, unknowingly and unintentionally, we were extremely lucky when we used as model substrates commercial proteins such as BSA, lysozyme and RNase, that were all recognized (as we learnt later) by this ligase and via a similar targeting motif - their N-terminal residue.”
“Interestingly, the ligase involved in BSA ubiquitination is E3a that was discovered during my graduate studies.”
Looking for tweets for ligase.