from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of a class of enzymes that catalyze the linkage of two molecules, generally utilizing ATP as the energy donor. Also called synthetase.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of a group of enzymes that catalyze the binding of two molecules; synthetase.
from the GNU version of the Collaborative International Dictionary of English
- n. An enzyme which catalyzes creation of a covalent bond between two substrates, resulting in a larger product which is a combination of the two starting materials; especially, DNA ligase, an enzyme which creates a phosphate bond between 5′ and 3′ ends of a DNA chain, resulting in a longer chain of DNA. DNA ligase is important in normal biosynthesis of DNA in the replication cycle of cells.
S., and Ciechanover, A. (1983) "Components of ubiquitin-protein ligase system".
DNA is cut-up but don't be afraid/Yo Jackteria has an enzyme called ligase/An enzyme that will definitely
Jackteria has an enzyme called ligase/An enzyme that will definitely
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DNA polymerase, Pol I, extends the DNA from the free 3'-OH using its exonuclease activity to replace the nucleotide of the damaged base, as well as a few downstream, followed by sealing of the new DNA strand by DNA ligase.
Prediction and evolution of E3 ubiquitin ligase targets
One of them is an RNA ligase with weak polymerase activity.
Beta lactamases have kept these activities, despite structural changes which have resulted in losing DD-peptidyl ligase activity, if these activities are kept, then the enzyme is more robust than Axe contends but to be fair this is harder to monitor in the kinds of experiments Axe did.. gutbag
At this point, however, unknowingly and unintentionally, we were extremely lucky when we used as model substrates commercial proteins such as BSA, lysozyme and RNase, that were all recognized (as we learnt later) by this ligase and via a similar targeting motif - their N-terminal residue.
Interestingly, the ligase involved in BSA ubiquitination is E3a that was discovered during my graduate studies.
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