American Heritage® Dictionary of the English Language, Fourth Edition
- n. A colorless crystalline alkaloid, C20H24N2O2, resembling quinine and used in treating malaria and certain heart disorders.
Century Dictionary and Cyclopedia
- n. A base (C20H24N2O2) isomeric with quinine, and occurring associated with it in some cinchona barks. It crystallizes in large transparent prisms, almost insoluble in water, but tolerably soluble in alcohol. It neutralizes acids, and forms salts with them which much resemble the corresponding quinine salts, but crystallize more easily. Their action on the system is similar to that of quinine, but less powerful. Also called
GNU Webster's 1913
- n. (Chem.) An alkaloid isomeric with, and resembling, quinine, found in certain species of cinchona, from which it is extracted as a bitter white crystalline substance; conchinine. It is used somewhat as a febrifuge.
- n. cardiac drug (trade names Quinidex and Quinora) used to treat certain heart arrhythmias
“What we have done is recognized that you can inhibit ones ability to metabolize dextromethorphan by adding quinidine, which is a therapeutic.”
“You could consider changing the way you are delivering quinidine which is your 2D6 inhibitor, you could consider looking at other 2D6 inhibitors that might produce the same thing or you might just want to develop a new [analong] for dextromethorphan.”
“QT-prolonging agents (eg, quinidine, sotalol, thioridazine), quinolones (eg, ciprofloxacin), or streptogramins (eg, mikamycin) because serious, possibly life-threatening side effects on the heart or irregular heartbeat may occur”
“Quinine, a famous malaria treatment, and quinidine, an antiarrhythmic medication, are made from the bark of the cinchona tree.”
“Generic pharmaceuticals are not new since even before 1965 several products appeared on the market such as phenobarbitol, digoxin, quinidine, and many others and nobody paid much attention to them.”
“Reserpine … quinidine … succinylcholine … he repeated as he wrote in his notebook.”
“In patients with heart disease, cyclic antidepressants may produce quinidinelike arrhythmias; if these arrhythmias develop, they should be treated as one would treat a quinidine overdose.”
“- Do not associate with drugs predisposing to the occurrence of "torsades de pointes": antiarrhythmic drugs (quinidine, disopyramide, sotalol), drugs inducing hypokaliemia”
“The gray bark of Huanuco is derived from _Cinchona micrantha_, which is characterized by its yield of cinchonine, and the Loxa or Loja barks are furnished in part by _Cinchona officinalis_, and are especially rich in quinidine.”
“Their great value depends upon the presence of certain alkaloid substances called quinine, cinchonine, and quinidine, which exist in the bark in combination with tannic and other acids.”
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