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To discover whether pathogens could be induced to mount such a defense in macrophages, the St. Jude team studied the arginase-inducing activity of the microorganisms that cause tuberculosis and toxoplasmosis, as well as a relative of tuberculosis,
However, toxoplasmosis is a rare disease in the United States and is one that can easily be avoided.— RNews - TOP STORIES
They found that mice genetically engineered to lack arginase only in their macrophages showed superior resistance to tuberculosis and toxoplasmosis.
However, some pathogens, such as those that cause tuberculosis and toxoplasmosis, have evolved to live and proliferate within macrophages themselves.
Such drugs might suppress such diseases as tuberculosis and toxoplasmosis by increasing the ability of macrophages to make nitric oxide.
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