proximal

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“
Ofatumumab is a novel, investigational, fully human monoclonal antibody that targets a membrane-proximal (close to the cell surface) small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule of B-cells. (

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Definitions (6)

Toggle American Heritage definitions American Heritage Dictionary (2)

  1. adjective Nearest; proximate.
  2. adjective Anatomy Nearer to a point of reference such as an origin, a point of attachment, or the midline of the body: the proximal end of a bone.

Toggle Century definitions Century Dictionary (2)

Toggle GNU Webster definitions GNU Webster's 1913 (1)

Toggle WordNet definitions WordNet (1)

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Examples (50)

  • Here, we show that peaks of promoter-proximal polymerase reside on ~30\% of human genes, transcription extends beyond pre-mRNA 3 'cleavage, and antisense transcription is prevalent. —  CiteULike: Everyone's library
  • Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. —  CiteULike: Everyone's library
  • It's called proximal - distal, dorsal - ventral, anterior - posterior. —  ScreenTalk
  • Nor are couples in LDRs any more likely to cheat on each other than are "proximal" couples, although the LDR mates do tend to worry more about the risk of an affair, studies show.
  • However, telomerase deficiency also decreased the frequency of translocation formation following multiple HO-endonuclease catalyzed DNA double-strand breaks at telomere proximal or distal sequences before, during and after crisis. —  PLoS ONE Alerts: New Articles
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Etymologies (2)

Toggle American Heritage etymologies American Heritage Dictionary (1)

  1. From Latin proximus, nearest; see proximate.

Toggle Century etymologies Century Dictionary (1)

  1. = Old French proximal; from Latin proximus, nearest: see proxime.
 

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/ˈprɑksɪməl/
by American Heritage

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