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Definitions

American Heritage® Dictionary of the English Language, Fourth Edition

  1. n. Informal Sister.

Century Dictionary and Cyclopedia

  1. n. A girl; a sweetheart; a jill: a familiar term.
  2. n. A familiar term of address to a little girl.
  3. n. An obsolete form of sice.

Wiktionary

  1. n. Shortened form of sister.

GNU Webster's 1913

  1. n. A colloquial abbreviation of sister.
  2. n. Six. See sise.

WordNet 3.0

  1. n. a female person who has the same parents as another person

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‘sis’ has been looked up 1096 times, added to 6 lists, and has a Scrabble score of 3. It's also a palindrome.