from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun An abnormal condition of a part, organ, or system of an organism resulting from various causes, such as infection, inflammation, environmental factors, or genetic defect, and characterized by an identifiable group of signs, symptoms, or both.
  • noun A condition or tendency, as of society, regarded as abnormal and harmful.
  • noun Obsolete Lack of ease; trouble.

from The Century Dictionary.

  • To make uneasy; pain; distress.
  • To affect with disease; make ill; disorder the body or mind of: used chiefly or only in the passive voice or the past participle.
  • noun Lack or absence of ease; uneasiness; pain; distress; trouble; discomfort.
  • noun In pathology: In general, a morbid, painful or otherwise distressing physical condition, acute or chronic, which may result either in death or in a more or loss complete return to health; deviation from the healthy or normal condition of any of the functions or tissues of the body.
  • noun Specifically— An individual case of such a morbid condition; the complex series of pathological conditions causally related to one another exhibited by one person during one period of illness; an attack of sickness.
  • noun A special class of morbid conditions grouped together as exhibiting the same or similar phenomena (symptoms, course, result), as affecting the same organs, or as due to the same causes: as, the diseases of the lungs, as pneumonia, consumption; the diseases of the brain.
  • noun Any disorder or depraved condition or element, moral, mental, social, or political.
  • noun Certain inflammatory conditions of joints attendant on locomotor ataxia.
  • noun See the adjectives.

from the GNU version of the Collaborative International Dictionary of English.

  • transitive verb obsolete To deprive of ease; to disquiet; to trouble; to distress.
  • transitive verb To derange the vital functions of; to afflict with disease or sickness; to disorder; -- used almost exclusively in the participle diseased.
  • noun obsolete Lack of ease; uneasiness; trouble; vexation; disquiet.
  • noun An alteration in the state of the body or of some of its organs, interrupting or disturbing the performance of the vital functions, and causing or threatening pain and weakness; malady; affection; illness; sickness; disorder; -- applied figuratively to the mind, to the moral character and habits, to institutions, the state, etc.
  • noun See under Germ.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun pathology An abnormal condition of the body or mind that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired.
  • noun by extension Any abnormal or harmful condition, as of society, people's attitudes, way of living etc.
  • verb obsolete To cause unease; to annoy, irritate.
  • verb To infect with a disease.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun an impairment of health or a condition of abnormal functioning


from The American Heritage® Dictionary of the English Language, 4th Edition

[Middle English disese, from Old French : des-, dis- + aise, ease; see ease.]

from Wiktionary, Creative Commons Attribution/Share-Alike License

Middle English disese, from Anglo-Norman desese, disaise, from Old French desaise (dis- +‎ ease). Displaced native Middle English adle, audle ("disease") (from Old English ādl ("disease, sickness")), Middle English cothe, coathe ("disease") (from Old English coþu ("disease")).


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