Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • transitive v. To pinch, pluck, or twist sharply.
  • transitive v. To adjust; fine-tune.
  • transitive v. To make fun of; tease.
  • n. A sharp, twisting pinch.
  • n. A teasing remark or action; a joke.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A sharp pinch or jerk; a twist or twitch.
  • n. Trouble; distress; tweag.
  • n. A slight adjustment or modification.
  • n. A prostitute.
  • v. To pinch and pull with a sudden jerk and twist; to twitch.
  • v. To adjust slightly; to fine-tune.
  • v. To twit or tease.
  • v. To abuse methamphetamines, especially crystal meth.

from the GNU version of the Collaborative International Dictionary of English

  • n. A sharp pinch or jerk; a twist or twitch.
  • n. Trouble; distress; tweag.
  • n. A prostitute.
  • transitive v. To pinch and pull with a sudden jerk and twist; to twitch.

from The Century Dictionary and Cyclopedia

  • To twitch; pinch and pull with or as with a sharp jerk; twinge.
  • n. A sharp pinch or jerk; a twitch.
  • n. A pinch; dilemma; perplexity: as, to be in a sad tweak. E. Phillips, 1706. Also tweag, tweague.
  • n. A prostitute.
  • n. A whoremonger.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. a squeeze with the fingers
  • v. pinch or squeeze sharply
  • v. pull or pull out sharply
  • v. adjust finely

Etymologies

Probably variant of dialectal twick, from Middle English twikken, from Old English twiccian.
(American Heritage® Dictionary of the English Language, Fourth Edition)
From Middle English twikken, from Old English twiccian ("to pluck"), cognate with twitch. (Wiktionary)

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